Reduction of Serum Ubiquinol-10 and Ubiquinone-10 Levels by Atorvastatin in Hypercholesterolemic Patients

Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients.

Reduction of serum cholesterol levels with statin therapy decreases the risk of coronary heart disease. Inhibition of HMG-CoA reductase by statin results in decreased synthesis of cholesterol and other products downstream of mevalonate, which may produce adverse effects in statin therapy. We studied the reductions of serum ubiquinol-10 and ubiquinone-10 levels in hypercholesterolemic patients t...

Serum ubiquinone-10 in a pediatric population.

question in the cTnT-ESRD debate is the prognostic importance of this biochemical abnormality, and particularly whether these patients require some modification of their treatment. We have followed 81 hemodialysis patients over a 20-month period and have found no increase in mortality in those with increased cTnT (7 deaths from 43 patients) compared with those with cTnT within reference values ...

Kinetics of electron and proton transfer to ubiquinone-10 and from ubiquinol-10 in a self-assembled phosphatidylcholine monolayer.

Upon incorporating from 0.5 to 2 mol% ubiquinone-10 (UQ) in a self-assembled monolayer of dioleoylphosphatidylcholine (DOPC) supported by mercury, the kinetics of UQ reduction to ubiquinol-10 (UQH2) as well as that of UQH2 oxidation to UQ were investigated in borate buffers over the pH range from 8 to 9.5 by cyclic voltammetry. A general kinetic approach was adopted to interpret the dependence ...

Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum

Objective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats. Materials and Methods: Rats were fed high-fat or a normal fed diet for 12-week then treated with 5% guar gum in their regime during a 28 days peri...

Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum